NINJ1 Defines a Hyperinflammatory Monocyte State Associated with Severe COVID-19

Background/Objectives: Severe coronavirus disease 2019 (COVID-19) is characterized by dysregulated immune activation and excessive inflammation; however, the specific immune cell states that drive disease progression remain incompletely understood.

Methods

Here, we integrated single-cell RNA sequencing analysis of peripheral blood mononuclear cells with clinical validation to investigate the role of Ninjurin-1 (NINJ1) in COVID-19-associated immune dysregulation.