Intraperitoneal Fetuin-A Modulates HMGB1-Associated Inflammatory Remodeling in Experimental Endometriosis

Background/Objectives: Endometriosis is a chronic inflammatory disorder characterized by ectopic endometrial-like lesions, inflammatory activation, angiogenesis, and tissue remodeling. Fetuin-A has been implicated in inflammatory regulation; however, its effects on HMGB1 mRNA expression and lesion-remodeling markers in endometriosis remain unclear. This study investigated whether intraperitoneal Fetuin-A is associated with changes in systemic inflammation and lesion-associated remodeling in a surgically induced rat model of endometriosis.