Abstract / Summary
Carotid intima-media thickness (CIMT) is an established marker of subclinical atherosclerosis, but its reliance on ultrasound equipment and trained operators limits its suitability for large-scale screening. Retinal fundus photography may offer a more scalable approach to vascular assessment, as it contains retinal vascular features associated with systemic cardiovascular health and can be acquired quickly and non-invasively. This study proposes a two-stage transfer learning framework for CIMT-based cardiovascular risk classification. An attention-enhanced EfficientNet-B4 is first pretrained on the Asia Pacific Tele-Ophthalmology Society 2019 Blindness Detection dataset and subsequently transferred to a weight-sharing Siamese architecture to classify the China Fundus Carotid Intima-Media Thickness dataset. Across ten independent initializations, the proposed model achieved an average macro-F1 score of 77.81% and an area under the receiver operating characteristic curve of 84.08% on the validation set and 78.29% and 85.22%, respectively, on the test set. It achieved overall higher point estimates for performance metrics than those previously reported for the Siamese ResNeXt baseline model with squeeze-and-excitation attention, and demonstrated a reduced disparity in class-wise performance. Grad-CAM analysis further revealed differences in the spatial activation patterns between models trained under different experimental configurations. Overall, these findings support the feasibility of fundus imaging as a scalable and non-invasive approach to CIMT-based cardiovascular risk assessment.