Case Report: lipoblastoma-like tumor of the tongue

Lipoblastoma-like tumor (LLT) is a distinctive adipocytic neoplasm most commonly arising in the vulva of women. Lingual involvement is extremely rare. Herein, we present a case of LLT occurring in the tongue and review the relevant literature. The patient was a 41-year-old female who presented with a mass on the right lateral border of the tongue for 6 months. Microscopic examination revealed the typical features of LLT. Immunohistochemically, the tumor was positive for CD34 and vimentin, with partial positivity for CDK4 and S-100, and negative for Rb, p16, and MDM2. Fluorescence in situ hybridization (FISH) demonstrated no DDIT3 rearrangement or MDM2 amplification. Next-generation sequencing (NGS) detected no significant genetic alterations. The tumor was completely resected, and no recurrence was observed at 19 months of follow-up. Given the rarity of lingual LLT—of which only three cases, including ours, have been reported—this report expands the current knowledge base and emphasizes the need for accurate diagnosis and long-term patient surveillance.