P300 latency prolongation and executive dysfunction in systemic sclerosis: A multimodal cognitive assessment

Objectives

The objective of the study is to evaluate cognitive functions in patients with systemic sclerosis (SSc) using auditory event-related potentials (P300) and the Stroop colour-word test, and to determine their correlation with disease status. Materials and Methods: This cross-sectional observational study included 30 clinically diagnosed SSc patients (mean age 36.93 ± 6.27 years, 96.7% females) and 30 age- and sex-matched healthy controls. P300 auditory event-related potentials were recorded at Fz, Cz and Pz electrode sites using an oddball paradigm. Cognitive performance was assessed using the computerised Stroop colour-word test, measuring reaction times in congruent and incongruent conditions. Correlation analysis assessed relationships between cognitive parameters and disease duration.