JLUMHS
Clinical Outcome of Zinc Plus Saccharomyces Boulardii versus Zinc Alone in the Treatment of Acute Diarrhea in Children Under 5 Years of Age
By Muhammad Hammad Riaz.
Abstract
Objective
To compare the time taken to resolve diarrhea, and the time taken to resolve vomiting in children (under 5 years of age) with zinc plus Saccharomyces boulardii (S. boulardii) versus zinc alone.
Methodology
This randomized controlled trial was conducted at the Department of Pediatric Medicine, Children's Hospital and Institute of Child Health, Multan, Pakistan, from February to July 2025. A total of 276 children (138 in each group) aged up to 5 years presenting with acute diarrhoea were enrolled using simple random sampling. After randomization, Group-A patients received zinc plus S. boulardii, while Group-B patients received zinc alone. All patients were treated following the institutional treatment protocol. The time taken to resolve diarrhea, and vomiting was noted and compared between the study groups. Data were analyzed using IBM SPSS 26.0.
