Zagazig University Medical Journal
Evaluation of Rivaroxaban plus Aspirin versus Clopidogrel plus Aspirin in peripheral artery disease patients after Infrainguinal Endovascular Revascularization
By Mostafa Mahmoud Elsayed Mahmoud, Ayman Mohamed Samir Zaki, Mahmoud Ahmed Elsabagh and 1 others.
Abstract
Background
The best antithrombotic regimen following infrainguinal endovascular revascularization remains unknown. This study compared rivaroxaban with aspirin versus clopidogrel plus aspirin in patients with chronic limb-threatening ischemia.
Methods
This prospective randomized clinical trial included 53 patients with Rutherford categories 4-6 who underwent technically and clinically successful infrainguinal endovascular revascularization. Computer-generated simple randomization allocated 24 patients to dual pathway therapy (DPT; rivaroxaban 2.5 mg twice daily plus aspirin 100 mg once daily) and 29 patients to dual antiplatelet therapy (DAPT; clopidogrel 75 mg once daily plus aspirin 100 mg once daily). Both regimens were continued for 6 months. Patients were assessed at 1 : 6 months using the ankle-brachial index (ABI), Rutherford classification.
