Dose and Intensity of Warfarin Therapy are Associated with Coronary Artery Calcification in a Low-Risk Cohort

Abstract: Background: Warfarin inhibits activation of vitamin K-dependent proteins, including matrix Gla protein (MGP), a potent vascular calcification inhibitor. Effects of warfarin dose and intensity of anticoagulation on coronary artery calcium (CAC) in individuals without traditional cardiovascular risk factors are unclear.

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