A Multimodal Approach to Extended Periorbital Rejuvenation: Clinical Outcomes and Time Course in a Prospective Single-Centre Study

Background

The periorbital region is characterized by early visible signs of aging, including wrinkles, fine lines, and skin laxity. While surgical procedures such as blepharoplasty have traditionally been used to address these changes, minimally invasive aesthetic treatments such as polynucleotides (PNs), botulinum toxin, and hyaluronic acid (HA) fillers are increasingly preferred due to lower risks and shorter recovery times. Although these treatments are widely used, real-world data on the efficacy and safety of such combination protocols remain limited.