Clinical Cosmetic and Investigational Dermatology
A New Insight into Acne Pathogenesis: Multi-Omics Links a Metabolite to C. acnes Expansion and Lipid Accumulation
By Xiaojing Song, Junyou Chen, Hung Chan and 9 others.
Abstract
Background
Gut microbiota dysbiosis is implicated in dermatoses, including acne vulgaris. However, gut microbial and metabolomic profiles in acne remain uncharacterized.
Methods
We performed metagenomic and metabolomic analyses on fecal samples from 29 acne patients and 20 healthy controls. Functional annotations utilized multiple databases. Integrated metagenomic-metabolomic analysis was conducted to identify metabolites, and their effects were subsequently validated in a mouse acne model. Finally, a five-fold cross-validated random forest model evaluated discriminatory capacity of microbial, metabolic, and multi-omics signatures for acne and its subtypes.