Single‑Cell in silico Perturbation Uncovers a Ferroptosis Regulatory Network for Cigarette Smoke‑Induced Skin Aging and Identifies Dapivirine as a Candidate Agent

Objective

Cigarette smoke exposure induces cutaneous ferroptosis and accelerates skin aging, yet the core regulatory genes and targeted interventions remain unclear. This study aimed to identify key ferroptosis-driving genes underlying smoke-induced skin senescence, clarify their mechanisms, and screen candidate small molecules that reverse smoke-related skin damage.