Abstract / Summary
Abstract This study explored sustainable working life before and after an ischemic heart disease (IHD) diagnosis, considering genetics and early life environmental factors, and explored differences by sex and common mental disorders (CMDs). A prospective cohort of Swedish twins aged 20–60 years included 1929 individuals diagnosed with IHD and 3858 matched controls. Sustainable working life was assessed using national register data over six year. Generalized estimating equations (GEE) were used to calculate odds ratios (OR) with 95% confidence intervals (CI). Conditional models for complete twin pairs accounted for genetic and early life environmental confounding. Analyses were stratified by sex and CMDs. We found that both those with and without IHD had a decreased probability of sustainable working life three years after the cohort entry year, with IHD patients showing a slightly lower probability. No significant differences were observed based on sex or CMDs. In conditional models, associations between IHD and sustainable working life were attenuated among monozygotic twins, suggesting genetic and early life environmental influences. IHD is associated with a lower probability of sustainable working life after diagnosis. Findings highlight the importance of considering genetic and early life factors in understanding the effects of IHD on sustainable working life.