Abstract / Summary
Abstract Aim Omentin-1 is an adipokine associated with insulin sensitivity and inflammatory processes, while the ITLN1 Val109Asp (rs2274907) variant has been implicated in metabolic phenotypes. We investigated its association with circulating omentin-1 and a metaflammatory phenotype in men with type 2 diabetes mellitus (T2DM). Methods In this cross-sectional study, 225 men with T2DM were genotyped for ITLN1 Val109Asp (TT, AT, and AA). Anthropometric, glycaemic, insulin-resistance, lipid, inflammatory, and haematological parameters were compared across genotypes. Associations between circulating omentin-1 and metabolic, inflammatory, and haematological parameters were assessed using Spearman correlation. Logistic regression evaluated associations between the variant and obesity under dominant, recessive, and additive models. Receiver operating characteristic analysis assessed discrimination of low circulating omentin-1. Results Omentin-1 concentrations decreased progressively from TT to AT to AA genotypes [749.6, 627.9, and 483.2 ng/L, respectively; P < 0.001], whereas BMI, HOMA-IR, METS-IR, lipid abnormalities, and inflammatory markers showed less favourable profiles in the AA group. Genotype and allele distributions differed across BMI phenotypes (P = 0.027 and P = 0.002, respectively). Omentin-1 was inversely correlated with BMI, WHR, HOMA-IR, and METS-IR and positively correlated with QUICKI across genotype groups. Each additional A allele was associated with higher odds of obesity (age-adjusted OR 1.97, 95% CI 1.27–3.05; P = 0.002). IL-8 showed the highest discrimination for low omentin-1 (AUC 0.976, 95% CI 0.959–0.992). Conclusion ITLN1 Val109Asp was associated with circulating omentin-1 concentrations and a metaflammatory phenotype in men with T2DM, linking genetic variation with a metabolic–inflammatory profile.