Abstract / Summary
Abstract The demand for platelet transfusions using apheresis-derived platelet concentrates is increasing due to the minimal side effects experienced by donors. 1,2 However, platelet apheresis results in a decrease in specific circulating cells, and other cellular components may also be affected. 3 Anticoagulants are required during apheresis to prevent activation of cellular and plasma components and maintain blood fluidity. Citrate anticoagulants act as chelators of ionized calcium and magnesium. 4,5 Although platelet apheresis provides benefits to recipients, it may cause donor-related changes that require monitoring. A prospective cross-sectional analytical study was conducted among 40 platelet apheresis donors at Dr. M. Djamil General Hospital Padang. Hematological and biochemical parameters were measured before and after the procedure. T Significant differences were observed in hemoglobin, erythrocytes, hematocrit, mean corpuscular hemoglobin, red cell distribution width, leukocyte count, platelet count, platelet distribution width, mean platelet volume, plateletcrit, and platelet large cell ratio (P < 0.05). No significant differences were found in mean corpuscular volume or mean corpuscular hemoglobin concentration (P > 0.05). Calcium and magnesium levels significantly decreased (P < 0.05), whereas ferritin showed no significant change (P > 0.05). Regular monitoring, particularly among frequent donors, is necessary to ensure donor safety and comfort.