Abstract / Summary
Abstract Purpose This study aimed to evaluate clinically and radiographically the efficacy of injectable platelet-rich fibrin (I-PRF) intraarticular injection in the management of temporomandibular joint (TMJ) internal derangement. This research addressed the following primary question: Did the administration of I-PRF lead to statistically significant clinical improvements (e.g., reduction in joint pain and increase in maximum mouth opening [MMO]) and positive MRI changes (change in disc position)? Methods Twenty female patients who were diagnosed with internal derangement and did not respond to conservative treatment were enrolled in this randomized clinical investigation. Patients were divided into two equal groups at random: the study group received an intraarticular injection of I-PRF after arthrocentesis, whereas the control group received an intraarticular injection of hyaluronic acid (HA) after arthrocentesis. Maximum mouth opening (MMO), joint clicking, lateral and protrusive movements, and pain severity as measured by the Visual Analog Scale (VAS score) were all included in the clinical examination. MRI was done both before and six months after surgery. Results Over time, both groups showed notable improvements in pain and MMO following surgery. MMO was similar in the I-PRF and HA groups at six months. At six months, however, the I-PRF group's pain score was statistically lower than the HA group's. Both groups saw significant improvements in TMJ clicking. Both groups' MRI results showed sustained anterior disk displacement. Conclusion I-PRF was successful in treating TMJ internal derangement, especially in terms of increasing mouth opening, lowering joint clicking, and resolving joint effusion.