Abstract / Summary
Abstract Marginal Zone Lymphoma encompasses a heterogeneous clinical and histopathological entity that originates from B cells in the marginal zones of lymphoid tissues. This article presents an initial, unexpected case of Mantle Zone Lymphoma, characterized by prolonged prothrombin time (PT) and partial thromboplastin time (PTT) before elective cataract surgery rather than the typical lymphoproliferative signs and symptoms. The patient was diagnosed with Marginal Zone Lymphoma associated with lupus anticoagulant antibodies and received R-CVP (rituximab, vincristine, and cyclophosphamide) chemotherapy protocol. As such, this article highlights the association between malignancies and coagulation abnormalities that clinicians should be aware of in order to tailor anticoagulation therapy. This case underscores the importance of a structured diagnostic approach to prolonged coagulation studies, particularly the use of mixing studies and lupus anticoagulant testing to differentiate clotting factor deficiencies from the presence of an inhibitor.