Abstract / Summary
Abstract Background Autogenous Demineralized Dentin Matrix (ADDM) provides a bio-interactive, growth-factor-enriched substitute for deproteinized bovine bone mineral (DBBM) xenograft. This research assessed the radiographic and clinical results of socket preservation utilizing ADDM in contrast to DBBM within a membrane-free regimen. Methods In this prospective, randomized controlled trial (RCT), 40 patients requiring maxillary premolar extractions were randomly assigned (1:1) to undergo socket grafting with either ADDM ( n = 20) or DBBM ( n = 20) without a barrier membrane. Radiographic parameters including bucco-lingual ridge width, marginal bone loss (MBL), and volumetric bone change were measured via Cone-Beam Computed Tomography (CBCT) at baseline and 6 months postoperatively. Clinical parameters specifically keratinized Gingival Width (KGW) and Visual Analogue Scale (VAS) pain scores were recorded over 7days and 6 months follow-up period. Results At 6 months, both cohorts exhibited significant intra-group reductions in bucco-lingual ridge width, bone volume, KGW, and VAS pain scores over time ( p > 0.05). However, no significant differences emerged between ADDM and DBBM across any evaluated outcomes, including bucco-lingual ridge width loss at the crest ( p = 0.0920), middle ( p = 0.9013), or apex ( p = 0.3641), mesial ( p = 0.1911) or distal ( p = 0.6362), MBL, volumetric bone loss ( p = 0.4246), KGW alterations ( p = 0.7515), or postoperative VAS scores. Conclusions ADDM is non-inferior to DBBM for maintaining hard and soft tissue dimensions and limiting post-extraction ridge resorption when using a membrane-free socket preservation approach. Consequently, ADDM serves as a viable, host-derived alternative to traditional xenografts. Trial registration ClinicalTrials.gov, NCT07777588, retrospectively registered on 15 August 2026