Abstract / Summary
Abstract Background and Purpose : Migraine is associated with oxidative imbalance and stress-related neuroendocrine mechanisms. This study evaluated serum copeptin and global oxidative imbalance in patients with interictal migraine and matched healthy controls. Methods : This exploratory matched case–control study included 43 patients with interictal migraine and 43 age- and sex-matched healthy controls. Serum copeptin was measured by enzyme-linked immunosorbent assay, total antioxidant status (TAS) and total oxidant status (TOS) were assessed colorimetrically, and oxidative stress index (OSI) was calculated as the principal marker of global oxidative imbalance. Clinical assessments included affective symptoms, migraine-related disability, and pain severity. Correlation, receiver operating characteristic (ROC) curve, and multivariable logistic regression analyses were performed. Results : Patients with migraine had lower TAS and higher TOS, OSI, and copeptin levels than controls (all p < 0.001). After adjustment for depressive and anxiety symptoms and correction for multiple testing, copeptin was not significantly associated with clinical severity measures. OSI showed good discriminatory performance for migraine status (area under the curve (AUC) = 0.856, 95% confidence interval = 0.780–0.931), whereas copeptin showed moderate performance (AUC = 0.730, 95% confidence interval = 0.623–0.838). In exploratory multivariable models, both OSI and copeptin remained associated with migraine status after adjustment for demographic and affective variables. Conclusions : Interictal migraine was associated with global oxidative imbalance and elevated serum copeptin levels. OSI showed stronger association with migraine status, whereas copeptin may provide complementary information on stress-related neuroendocrine activity. These hypothesis-generating findings require validation in larger prospective cohorts.