Abstract / Summary
Abstract Purpose Colorectal cancer is the second leading cause of cancer-related mortality worldwide. Incidence and mortality rates are rising in the Latin American and Caribbean region, yet limited data exist on the burden of and demographic factors associated with colorectal cancer in Grenada, West Indies. Methods This retrospective study analyzed temporal trends and disparities in colorectal cancer by age and sex from 2014 to 2023. Joinpoint regression evaluated temporal trends in mortality, and negative binomial regression assessed the relationship between mortality rates and predictor variables (age and sex). Results The results showed no significant temporal trend in mortality rates over the study period (Annual Percent Change [APC] = -2.19%; p = 0.614). Sex was not significantly associated with the death rate (Mortality Rate Ratio [MRR] = 0.92; p = 0.62). However, age was significantly associated with higher death rates from age 50 onward. The highest mortality rates were observed among individuals aged 60–69 years (MRR: 8.2; p < 0.001), 70–79 years (MRR: 7.8; p < 0.001), and 80–89 years (MRR: 6.8; p < 0.001). Conclusion These findings underscore the critical need to prioritize screening and early diagnosis among older populations to improve treatment outcomes. Further research on modifiable risk factors remains essential to inform targeted public health interventions.