Abstract / Summary
Abstract Background: Sepsis is a life-threatening condition characterized by dysregulated host response to infection. Reliable prognostic biomarkers are needed for early risk stratification. This study evaluated SCUBE-1 (Signal Peptide-CUB-EGF-Like Domain-Containing Protein-1) and routine hematological inflammatory indices—SIRI (Systemic Inflammation Response Index), NLR (Neutrophil-to-Lymphocyte Ratio), and PLR (Platelet-to-Lymphocyte Ratio)— as predictors of 28-day mortality in patients with sepsis.
Result: In this observational cross-sectional study, 84 patients with sepsis admitted to the High Care Unit and Intensive Care Unit of Dr. M. Djamil Hospital, Padang, Indonesia, from May to August 2026. Sepsis was defined by Sepsis-3 criteria. SCUBE-1 plasma levels were measured by sandwich ELISA, and SIRI, NLR, PLR were derived from complete blood count. The primary outcome was 28-day mortality. Receiver operating characteristic (ROC) analysis determined the optimal cut-off and predictive performance of each biomarker.