Abstract / Summary
Abstract Purpose To evaluate the clinical efficacy and safety of prostatic urethral lift (PUL) using a modified zero-angle firing and needle-guided puncture technique in men with symptomatic benign prostatic hyperplasia (BPH). Methods This prospective, single-arm, single-center study enrolled 12 patients who underwent modified PUL between December 2023 and August 2024. Perioperative outcomes were recorded, and IPSS, QoL, Qmax, PVR, and SHIM were assessed preoperatively and at 14, 30, 90 days, and 1 year postoperatively. Pre- and postoperative outcomes were compared using paired analyses.This prospective, single-center, single-arm exploratory study was prospectively registered at ClinicalTrials.gov (NCT07776158; registered on August 18,2026). Results All procedures were completed successfully without conversion. Mean operative time was 27.1 ± 11.2 minutes, with a mean of 4.4 ± 1.8 implants placed. At 90 days, IPSS decreased from 21.67 ± 6.47 to 5.17 ± 4.75 (P < 0.001), QoL improved from 4.08 ± 0.29 to 1.33 ± 1.07 (P < 0.001), and Qmax increased from 8.43 ± 3.84 to 14.95 ± 5.38 mL/s (P = 0.002). PVR decreased from 78.65 ± 98.42 to 39.60 ± 46.44 mL without statistical significance (P = 0.260). SHIM remained stable (P = 0.841). Early hematuria and urgency/dysuria were transient and managed conservatively. No severe complication, urinary tract infection, urethral stricture, or secondary surgery occurred. Symptom improvement was maintained at 1 year. Conclusion Modified PUL using zero-angle firing and needle-guided puncture appears feasible and safe, with durable symptom relief and preserved erectile function. Comparative studies are needed to confirm its clinical value.