Abstract / Summary
Abstract We aimed to identify non-pharmacological factors associated with inefficient glycemic control (IGC) among individuals with type 2 diabetes (T2D) in a Siberian urban sample. A cross-sectional data from a representative sample in Novosibirsk (HAPIEE Project), focusing on the individuals with T2D receiving glucose-lowering therapy (GLT) selected from wave-3 participants (n = 476 from 3898, 55–84 years) were analyzed. We have assessed diabetes history and duration, GLT use, cardiovascular disease (CVD) history, menopausal status, behavioral risk factors, self-rated health, sociodemographic characteristics, and objective measures. Associations with IGC were assessed using logistic regression. Glycemic targets were achieved in 35.3% of participants. In multivariable-adjusted model, IGC was positively associated with male sex, systolic blood pressure, diabetes duration ≥ 10 years and it’s family history, and inversely associated with smoking, independently of other factors. In sex-stratified analysis, IGC odds ratio was 3.5-fold higher in men with low physical activity versus high activity. In women, IGC odds ratio was 4.6-fold higher in those with diabetes duration ≥ 10 years, 2-fold higher in those with a diabetes family history, and consuming alcohol < 1 time/month versus abstiners. IGC was inversely related to smoking in women. We identified determinants of IGC in Siberians aged 55–84, informing region-specific diabetes management strategies.