Abstract / Summary
Abstract Objective To analyze the incidence features and postnatal outcomes of fetal congenital heart disease (CHD) for clinical reference. Methods Clinical data of fetal CHD diagnosed via fetal echocardiography from 2014 to 2023 were retrospectively analyzed. OR and 95%CI were adopted for statistical analysis. Results A total of 5112 fetal CHD cases were identified between 2014 and 2023, showing an increasing detection trend. Complete follow-up was achieved for 4959 pregnancies, including 2691 simple and 2268 complex CHD cases, with a gradual decline in the overall pregnancy termination rate over the decade. Complex CHD presented a markedly higher rate of adverse pregnancy outcomes than simple CHD (87.21% vs. 37.83%). Statistical analysis demonstrated that complex CHD and extracardiac anomalies significantly elevated the risks of pregnancy termination and neonatal death (all P < 0.001). Specifically, complex CHD conferred substantially higher risks of pregnancy termination and neonatal mortality, and CHD combined with extracardiac malformations also independently increased the risks of adverse perinatal outcomes. Conclusion The detected fetal CHD cases increased while pregnancy termination rate decreased. Complex CHD and combined extracardiac malformations are major risk factors for adverse pregnancy outcomes.