Inflammasome biology in preeclampsia: from Bnip3-mitophagy to Nlrp1-driven placental injury – a systematic review and translational roadmap

Although inflammasome activation has been repeatedly linked to preeclampsia, the field has tended to frame this biology around NLRP3 alone, leaving other sensors – particularly NLRP1 – and their mitochondrial upstream signals only partially examined. Recent experimental work hints at a more intricate narrative in which dysregulated BNIP3-mediated mitophagy and escalating mitochondrial ROS form a convergent pathway toward trophoblast injury. Yet no systematic review has stitched these elements together.