PLoS ONE
Repurposing auranofin and meclofenamic acid as energy-metabolism inhibitors and anti-cancer drugs
By Sara Rodríguez-Enríquez, Diana Xochiquetzal Robledo-Cadena, Silvia Cecilia Pacheco-Velázquez and 4 others.
Abstract
Objective
Cytotoxicity of the antirheumatic drug auranofin (Aur) and the non-steroidal anti-inflammatory drug meclofenamic acid (MA) on several cancer cell lines and isolated mitochondria was examined to assess whether these drugs behave as oxidative phosphorylation inhibitors.
