Abstract / Summary
Abstract Background Weaning is the liberation process from, or discontinuation of mechanical ventilatory support which comprises 40% of the of mechanical ventilation (MV) duration. The aim of this work was to compare the efficacy and safety of some different modalities of weaning from MV in cases had an acute respiratory failure (ARF). Methods This randomized interventional controlled study included 90 patients aged more than 18 years old, with an ARF on invasive MV. Patients were divided into 3 groups: Group I: shifted to pressure support ventilation (PSV). Group II: shifted to synchronous intermittent mandatory ventilation (SIMV) + PS. Group III: shifted to volume support ventilation (VSV). Results VSV had the highest weaning success rate, the shortest length on mechanical ventilation and ICU stay compared to PSV and SIMV + PS groups. However according to the cause of respiratory failure: patients with ARDS and Life-threatening asthma had the highest weaning success rate in patients on VSV then on PSV while Patients with AECOPD had the highest weaning success rate in patients on SIMV + PS. Conclusion PSV, SIMV, and VSV are safe and effective modalities for weaning patients with an ARF who are undergoing MV. VSV was associated with a higher overall weaning success rate than SIMV + PS and shorter durations of mechanical ventilation and ICU stay.