The Cardiothoracic Surgeon
Temporal context may shape the observed association between varenicline and outcomes after cardiac surgery
By Güney Sarıoğlu.
Abstract
Abstract Yan et al. reported favorable postoperative cardiovascular outcomes associated with preoperative varenicline use in cardiac surgery patients. While their findings provide valuable real-world evidence, the 20-year study period raises the possibility of calendar-time confounding, as both varenicline prescribing patterns and cardiac surgical care evolved substantially during this interval. Incorporating calendar year into matching or conducting era-stratified sensitivity analyses could help clarify whether the observed associations are independent of secular improvements in perioperative and cardiovascular care.
Keywords
- Cardiac Valve Diseases and Treatments
- Varenicline
- Context (archaeology)
- Perioperative
- Cardiac surgery
- Association (psychology)
- Matching (statistics)
- Open access
Source
Published in The Cardiothoracic Surgeon. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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