Abstract / Summary
Hemoglobin (Hb) and red cell distribution width (RDW) have been shown to be correlated with diabetic kidney disease (DKD). Building on this evidence, the present study employed a cross-sectional design to further investigate the potential association between the Hb-to-RDW ratio (HRR) and DKD in patients with type 2 diabetes mellitus (T2DM) in the intensive care unit (ICU). Our retrospective cross-sectional study, utilizing data from the MIMIC-IV database and through strict inclusion and exclusion criteria, ultimately identified 8,201 patients who were diagnosed with T2DM while hospitalized in the ICU. Using stratified random sampling by DKD status, the dataset was divided into a training set (5,741 cases) and a validation set (2,460 cases) at a 7:3 ratio. Using receiver operating characteristic (ROC) curve analysis, we compared the consistency of HRR, Hb, and RDW in distinguishing the presence or absence of DKD in the training and validation sets. Restricted cubic splines (RCS) were used to explore nonlinear dose-response relationships and determine the turning point for HRR in the training set. This study included a total of 8,201 patients. Multivariate logistic regression analysis showed that elevated HRR was negatively correlated with the risk of DKD ( P < 0.05). ROC curve analysis indicated that, in both the training and validation sets, HRR demonstrated slightly better discriminatory performance for DKD than the single indicators Hb and RDW ( P < 0.05). RCS analysis confirmed a nonlinear relationship between HRR and the risk of DKD, with an turning point of 6.9492. The results of this study indicate that there is a certain correlation between reduced HRR and the risk of DKD. The discriminative performance of HRR for DKD was slightly better than that of Hb or RDW used alone. Not applicable.