Abstract / Summary
To evaluate the discriminative ability of the prognostic nutritional index (PNI) and controlling nutritional status (CONUT) score in patients with pseudoexfoliation syndrome (XFS) and to identify factors independently associated with pseudoexfoliation syndrome. This retrospective case-control study included 178 age- and sex-matched controls and 177 XFS patients. Serum albumin, lymphocyte count, and total cholesterol were measured, and PNI and CONUT scores were calculated. Quantitative variables were compared using the Mann–Whitney U test, and categorical variables were analyzed with the Chi-square test. ROC curve analysis assessed the discriminative capacity of these indices. Multivariate binary logistic regression was performed to evaluate independent associations with XFS, adjusting for age, sex, diabetes mellitus, and hypertension. Patients with XFS had significantly lower PNI compared to controls (43.52 ± 3.32 vs. 44.58 ± 3.05; p = 0.005), whereas CONUT scores did not differ ( p = 0.407). ROC analysis showed modest discriminative ability for PNI (AUC = 0.547; 95% CI: 0.495–0.599; p = 0.074), while CONUT was not discriminative (AUC = 0.534; 95% CI: 0.477–0.590; p = 0.240). Higher PNI independently predicted lower odds of XFS (OR = 0.929; 95% CI: 0.871–0.991; p = 0.025). Lower PNI was statistically associated with XFS; however, its discriminative performance was limited. Further prospective studies are needed to determine whether PNI has clinical utility as a systemic marker in XFS. Not applicable. This was a retrospective case-control study and was not registered in a clinical trial registry.