Intravenous Cyclophosphamide Infusion and miRNA-29A, miRNA-16, IL-6, TGF-β1 Responses in Systemic Sclerosis Patients with Interstitial Lung Disease

Background

Systemic sclerosis (SSc) is characterised by organ fibrosis, microvascular damage and immunological dysregulation. With an aetiology that remains poorly understood, increasing evidence suggests that epigenetic alterations and inflammatory mechanisms play crucial roles in the pathogenesis of SSc.