Use of circulating microRNAs to identify high-risk adenomas among FIT+ patients undergoing screening colonoscopy

Abstract Background: Colonoscopy prevents colorectal cancer (CRC) but is invasive and resource intensive. Circulating microRNAs (miRNAs) may improve risk stratification of fecal immunochemical test (FIT)-positive individuals by identifying high-risk adenomas (HRAs). We evaluated the association of circulating miRNAs with HRAs and their contribution to risk prediction models (RPMs).