Antimicrobial Agents and Chemotherapy
Comparative adjuvant therapy to reduce vancomycin-associated nephrotoxicity in an animal model
By Yongqi Xiao, Nicholas S. Teran, Cole S. Hudson and 2 others.
Abstract
ABSTRACT Vancomycin is a mainstay antibiotic for serious gram-positive infections, but nephrotoxicity remains a major barrier to its optimal use. In this study, we compared the effectiveness of montelukast and zileuton as adjuvant strategies to reduce vancomycin-associated nephrotoxicity. Montelukast only had a marginal effect in vancomycin-treated animals, whereas zileuton significantly delayed nephrotoxicity onset. These findings support further formulation and dose-optimization studies to repurpose zileuton as a renal-protective adjuvant.
Keywords
- glycopeptide
- nephroprotectant
- acute kidney injury
- Open access
Source
Published in Antimicrobial Agents and Chemotherapy. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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