Pediatric Lichen Planus Pemphigoides in a Child With Sickle Cell Disease: Cyclosporine Induction and Dupilumab Maintenance

ABSTRACT Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disorder that combines lichenoid lesions of lichen planus with immunopathologic features of pemphigoid disease. We report an 8‐year‐old boy with homozygous sickle cell disease and severe atopic dermatitis who developed diffuse pruritic violaceous papules followed by tense bullae; subsequent histopathologic, immunofluorescence, and serologic findings confirmed LPP. The patient was initially treated with cyclosporine, with marked clinical improvement within 2–3 weeks. Dupilumab was subsequently initiated during the cyclosporine taper, and no recurrent bullae were observed through approximately 8 months of follow‐up.