Commercial Oat‐Based Cosmetic Ingredients Promote Antioxidant Capacity and Reduce Inflammatory Markers in Skin Cellular Stress Models: An Insight Into Molecular Mechanisms In Vitro

ABSTRACT Background Dermal products containing oat ( Avena sativa L.) have a wide range of benefits on human skin and are commonly incorporated into skincare products. Aims The study focused on evaluating the antioxidant, cytoprotective, and anti‐inflammatory potential of three commercial sources of oat bioactive compounds—Aura firm P, AvenaPLex, and Oat Lipid e. Methods Antioxidant activity was assessed by interaction with a stable 2,2‐diphenyl‐1‐picrylhydrazyl radical and measurement of H 2 O 2 consumed in a Fenton‐like reaction. The UVA‐protective potential was evaluated in human skin cells by measuring cell viability and reactive oxygen species (ROS) levels. The modulation of intracellular localization of nuclear factor erythroid 2‐related factor 2 (Nrf2) was investigated immunohistochemically. The anti‐inflammatory effect was evaluated in atopic dermatitis (AD)‐like models induced by tumor necrosis factor alpha and interferon gamma in vitro. Effects on nuclear factor kappa B signaling were also studied. Results Minimal effect on UVA‐induced damage was observed on cell viability, but all three oat‐based products significantly decreased ROS production. All products stimulated Nrf2 nuclear translocation. In AD‐like models, reductions in interleukin‐6 and interleukin‐8 levels were noted. The anti‐inflammatory activity of all tested products was associated with the moderate inhibition of p50 phosphorylation. Conclusion The studied oat‐based products have promising protective activity in skin cell stress models in vitro.