British Journal of Dermatology
Clinical–pharmacodynamic discordance in pemphigus: beyond conventional anti-desmoglein ELISA
By Aparna Palit, Tarun Sharma and Avik Mondal.
Abstract
The ADDRESS trial showed a disconnect between anti-desmoglein antibody titres and clinical disease activity. We discuss whether conventional ELISA titres adequately reflect pathogenic antibody activity and suggest that functional or epitope-resolved assays may provide complementary information in future studies of FcRn blockade.
Keywords
- Autoimmune Bullous Skin Diseases
- Open access
Source
Published in British Journal of Dermatology. The abstract is shown as published and remains the work of its authors; read the full article at the source.
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At a glance
- Published