ACS Pharmacology & Translational Science
Cardioprotection Is a Delivery Problem: A First-Medical-Contact Framework for Acute Myocardial Infarction
By Vibhudutta Awasthi, Tarun W. Dasari and Kenichi A. Tanaka.
Abstract
Abstract Dozens of agents that limit reperfusion injury preclinically have failed clinically. These failures are architectural, not biological: the right biology reaches the wrong place, as the wrong molecule, at the wrong time, judged by the wrong end point. We recast each as a design constraint and specify a staged regimen anchored at first medical contact.
Keywords
- Cardiac Ischemia and Reperfusion
- Cardioprotection
- Myocardial infarction
- Constraint (computer-aided design)
- Limit (mathematics)
- Reperfusion injury
- Regimen
- Open access
Source
Published in ACS Pharmacology & Translational Science. The abstract is shown as published and remains the work of its authors; read the full article at the source.
Prognia lists this article for reference and education. It is not medical advice. Always read the original and follow current guidelines and local protocols before acting on it.
