Photodiagnosis and Photodynamic Therapy
Quantitative analysis of choroidal parameters of intermediate and neovascular age-related macular degeneration using ultra-widefield swept-source OCTA
By Xianggui Zhang, Zhen Huang, Jiaying Cheng and 3 others.
Abstract
Purpose
To evaluate wide-field choroidal alterations in intermediate AMD (iAMD) and neovascular AMD (nAMD) using ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA).
Methods
This cross-sectional study included 40 iAMD eyes, 81 nAMD eyes, and 68 age-matched normal eyes. Eight choroidal parameters—thickness (ChT), volume (CV), vascularity index (CVI), vascular volume/area (CVV/a), stromal volume/area (CSV/a), stromal index (CSI), choriocapillaris density (CCD), and large choroidal vessel density (LCVD)—were measured across nine subfields using 24 × 20 mm scans. Generalized estimating equations (GEE) and receiver operating characteristic (ROC) analysis were used. Subgroup analyses evaluated the effects of treatment status and macular neovascularization (MNV) type within nAMD.