Molecular Metabolism
PI3K is the dominant signalling pathway recruited by IRS proteins to mediate their effects on metabolism and growth
By Steven J. Millership, Nadia Tyler-Rubinstein, Elaine E. Irvine and 7 others.
Abstract
Objectives
Insulin and Igf1 have pleiotropic effects on development, growth and metabolism. The activated insulin and IGF1 receptors engage insulin receptor substrate (IRS) proteins, intracellular adaptor molecules that recruit multiple downstream signalling pathways, including PI3K and GRB2-RAS-MAPK. Global deletion of IRS1 or IRS2 in mice results in divergent effects on growth, metabolism, and ageing. However, the precise signalling pathways recruited by IRS1 or IRS2 to mediate their physiological effects in vivo have not been defined.