Membranous-pattern Nephropathy with Monotypic IgA1-κ Deposits: A Rare Case Report

Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome, characterized by the deposition of subepithelial immune complexes1. In primary MN, these complexes are typically polytypic, composed of polyclonal immunoglobulins. Rare cases of MN with light chain–restricted deposits have been reported 2,3. In contrast to Randall-type monoclonal immunoglobulin deposition disease, which features punctate deposits along the inner glomerular basement membrane, these patients exhibit membranous granular deposits.

Published in Kidney International Case Reports. The abstract is shown as published and remains the work of its authors; read the full article at the source.

doi.org/10.1016/j.kintcr.2026.100169