Journal of Translational Autoimmunity
Age-dependent association of thyroid peroxidase antibodies with incident cardiovascular disease events: Insights from a longitudinal cohort study
By Farhad Shaker, Safdar Masoumi, Ladan Mehran and 4 others.
Abstract
Background
The relationship between thyroid autoimmunity and cardiovascular disease (CVD) is controversial, and age-specific effects are not well characterized. We examined associations between thyroid peroxidase antibodies (TPOAb) status and incident CVD.
Methods
In this prospective population-based cohort, 4825 adults aged ≥ 20 years without baseline CVD were identified. Survival analyses were conducted using a 1.5-year landmark approach. Mean follow-up after the landmark was 14.8 ± 3.3 years. TPOAb was analyzed as a log-transformed continuous variable, dichotomous status, and categorical levels. Cox proportional hazards models were used to estimate hazard ratios (HRs) with progressive adjustment for demographic, lifestyle, cardiometabolic, and thyroid-related factors. Effect modification by age was assessed using interaction and spline analyses.
