Multivariable-adjusted multi-omics signatures reveal gut microbial functional alterations and metabolic dysregulation in intrinsic capacity decline

Background

Intrinsic capacity (IC) decline is inherently correlated with aging, yet distinguishing specific IC-related biomarkers from general physiological aging markers remains a significant challenge. We aimed to identify multi-omics signatures associated with IC decline after adjustment for relevant covariates and to explore the functional pathways potentially involved in IC decline.