Subharmonic entrainment of thalamic gamma during deep brain stimulation for multiple sclerosis tremor

Deep brain stimulation (DBS) is an effective treatment for tremor arising from a range of neurological disorders, including Parkinson's disease (PD), essential tremor, and multiple sclerosis (MS). The ventral intermediate nucleus (VIM) of the thalamus is a well-established surgical target for tremor suppression [1]; however, the neurophysiological mechanisms through which VIM stimulation exerts its therapeutic effects remain incompletely understood.