Dermocosmetics for Periocular Aging: Evidence, Mechanisms, and Integration with Aesthetic Procedures. A Narrative Review

The periocular area, where facial skin is thinnest and most expressive, is often the first to reveal signs of aging. Aesthetic procedures can correct structural changes, but they do not replace daily, ongoing care. Dermocosmetics formulated specifically for the eye contour have become a standard complement to medical-aesthetic treatments, with potential preventive, corrective, and maintenance benefits. This narrative review summarizes the evidence on the efficacy and safety of these products and their role in a comprehensive approach to periocular rejuvenation. A literature search in PubMed (2010–2025) identified randomized trials, observational studies, and mechanistic research on periocular anatomy, active ingredients, and clinical outcomes. Retinoids, peptides, antioxidants, vasomodulators, and depigmenting agents improve hydration, firmness, pigment uniformity, and puffiness, particularly alongside aesthetic procedures. Most available studies, however, derive from finished multicomponent formulations rather than isolated ingredients; studies are short-term, industry-sponsored, and limited in participant diversity and endpoints, so further independent, long-term, periocular-specific studies are needed. Dermocosmetics for the eye contour may provide a noninvasive strategy that supports skin resilience and complements procedures within a comprehensive periocular rejuvenation strategy. Closer collaboration between dermatologists, aesthetic physicians, and cosmetic formulators would help translate this evidence into more consistent periocular rejuvenation outcomes. The skin around the eyes is thin and constantly in motion, hence, it is often the first part of the face to show fine lines, puffiness, and dark circles. Medical-aesthetic procedures, such as laser treatments, neuromodulators, or fillers, can improve structure and firmness, but they do not replace daily care. Dermocosmetic products, topical formulations developed with dermatological expertise, may play a key role in maintaining the results of procedures and in preventing early signs of aging. These products contain active ingredients such as retinoids, peptides, antioxidants, barrier-supporting ingredients, and compounds used for puffiness or dark circles, but their effects depend strongly on the final formulation and its tolerability in this delicate area. This review gathers the scientific evidence supporting their use in the periocular area. It shows that a personalized combination of medical and dermocosmetic strategies may provide better long-term results. Dermocosmetics are therefore best understood as a supportive part of eye-contour care, alongside medical-aesthetic procedures.