Abstract / Summary
Diffuse large B-cell lymphoma (DLBCL) is a challenging disease owing to its biological heterogeneity and variable outcomes. Single-nucleotide polymorphisms (SNPs) can significantly influence tumor susceptibility and prognosis. However, the clinical relevance of lipid metabolism-related SNPs in DLBCL remains unclear. We detected ten SNPs from eight genes related to lipid metabolism in 148 patients with DLBCL and 230 healthy controls. We examined the correlations between these SNPs and susceptibility, clinical features, and prognosis of patients with DLBCL. Our results indicated that PRKAG2 rs2727572 was associated with susceptibility to DLBCL, suggesting a potential role in disease occurrence. CPT2 rs1799822 was related to the Ann Arbor stage, whereas CYP19A1 rs10046 was associated with the risk stratification. FABP1 rs2197076 was correlated with treatment response, particularly the complete remission rate following chemotherapy. Furthermore, different genotype frequencies of CES1 rs8192950 were associated with survival, indicating its potential value for prognostic stratification. These results suggest that lipid metabolism-related SNPs may influence the pathogenesis and progression of DLBCL. However, this study is limited by sample size and the lack of an independent validation cohort. In conclusion, our findings provide novel insights that may inform future functional studies and therapeutic exploration in DLBCL.