Caspian Journal of Internal Medicine
Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran
By Sakineh Khatoon Gholamrezaei, Mohammad Samet, Amir Pasha Amelshahbaz and 2 others.
Abstract
Background
This study aimed to evaluate the effect of pirfenidone on lung CT scan lesions in patients with severe COVID-19.
Methods
In this cross-sectional study, data were extracted from the electronic medical records of patients with severe COVID-19 who received one of the following treatments: pirfenidone alone (n= 40), prednisolone alone (n= 55), pirfenidone combined with methylprednisolone (n= 18), or supportive care only (n= 32). Chest CT images taken at baseline and two months post-treatment were assessed by a trained radiologist. p< 0.05 was considered statistically significant.