Cytotoxic Effects of Dimethylamino Parthenolide on the Rheumatoid Arthritis Fibroblast-Like Synoviocytes Cell Line

Background

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease in which fibroblast-like synoviocytes (FLS) play a critical role in its pathogenesis. Due to the significant side effects associated with conventional treatments and the lack of response to the therapy in some patients, researchers are investigating novel therapeutic approaches that offer improved efficacy and a more favorable safety profile. This study aimed to investigate the cytotoxic activity of dimethylamino parthenolide (DMAPT) on the rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) cell line.