The diagnostic value of serum…

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Results

Serum NARC1 and vWF levels were significantly greater in the type 2 diabetes group, although serum Protein G3a levels were significantly lower (P<0.05) than in the healthy control group. Before therapy, the macrovascular lesion group's serum NARC1 and vWF levels were considerably higher than those of the simple diabetes group (P<0.05). After treatment, the levels of serum NARC1 and vWF in both groups were significantly lower than those before treatment. However, levels in the macrovascular lesion group remained higher than those in the simple diabetes group, and the difference was statistically significant (P<0.05). Before therapy, the macrovascular lesion group's serum Protein G3a level was significantly lower than that of the simple diabetes group (P<0.05). Although the difference was statistically significant (P<0.05), the group with macrovascular lesions still had a lower level than the group with simple diabetes. According to univariate analysis, the proportions of people aged ≥60 and with a diabetes course of ≥10 years, as well as low-density lipoprotein cholesterol and triglyceride levels, were considerably greater in the group with macrovascular lesions than in the group with uncomplicated diabetes, and the differences were statistically significant (P<0.05). Multivariate analysis revealed that patients with type 2 diabetes mellitus, increased levels of NARC1 and vWF were independent risk factors for macrovascular disease (P<0.05), whereas elevated serum Protein G3a levels were a protective factor for macrovascular disease in type 2 diabetes mellitus patients (P<0.05). The sensitivity of the combined detection of serum NARC1, vWF, and Protein G3a in diagnosing type 2 diabetes complicated with macrovascular lesions was 89.4%, the specificity was 90.0%, and the area under the curve (AUC) was 0.959. The AUC was significantly greater than that of NARC1 (Z=4.160, P<0.01) and vWF (Z=4.059, P<0.01). However, individual Protein G3a indications were found (Z=5.186, P<0.01).

The diagnostic value of serum neuroapoptosis-regulating invertase (NARC1), von Willebrand factor (vWF), and protein G3a levels in type 2 diabetes patients with macrovascular lesions

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