Impact of Isotretinoin Therapy on Thyroid Hormone Levels in Patients with Acne Vulgaris: A Systematic Review and Meta-Analysis

Introduction

Systemic isotretinoin is extensively used to treat moderate-to-severe acne vulgaris and may have systemic endocrine effects through the hypothalamic-pituitary-thyroid axis.

Objectives

To investigate the changes in thyroid hormone levels after commencement of systemic isotretinoin among patients with acne vulgaris.

Methods