Efficacy of Allopurinol and Febuxostat in the Treatment of Gout with Hyperuricemia – A Comparative Study

Objective

To compare the efficacy and effectiveness of Allopurinol with Febuxostat in the treatment of gout in hyperuricemia patients. Study Design: Quasi Experimental study. Place and Duration of Study: Department of Medicine, Pak-Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Dec 2024. Methodology: Patients aged 18-75 years, diagnosed with gout having serum uric acid levels >6.8 mg/dL were included. Patients were divided in two groups of 35 patients each. Group-A was given Allopurinol and Group-B was given Febuxostat. Serum uric acid levels measured at baseline and then at 2 weeks, 4 weeks and 6 weeks follow-ups and compared. Change of uric acid levels at each follow-up and mean reduction was compared between the two groups.