Gazi Medical Journal
Short-Term Real-World Clinical Outcomes of the Fixed-Ratio Combination of Insulin Glargine and Lixisenatide in Type 2 Diabetes
By Enes Üçgül, Burak Menekşe, Burçak Çavnar Helvacı and 2 others.
Abstract
Objective
To assess the short-term real-world effects of the fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) on glycemic control, body weight, insulin requirements, and the Fibrosis-4 (FIB-4) score in adults with type 2 diabetes mellitus (T2DM).
Methods
This retrospective study screened 122 adults initiated on iGlarLixi between January 1 and April 1, 2025. After excluding 40 patients who were receiving additional antidiabetic therapy and 12 who discontinued treatment due to intolerance or loss to follow-up, 70 patients were included in the final analysis. Body weight, body mass index, HbA1c, daily insulin dose, and FIB-4 were recorded at baseline and at 3 months. Paired t-tests or Wilcoxon signed-rank tests were used for continuous variables, and chi-square or Fisher’s exact tests were used for categorical outcomes.
